Molecular mechanisms of glucocorticoid action and selective glucocorticoid receptor agonists
نویسندگان
چکیده
منابع مشابه
Molecular mechanisms of glucocorticoid action and selective glucocorticoid receptor agonists.
Glucocorticoids (GC) are the most common used anti-inflammatory and immunosuppressive drugs in the treatment of rheumatic and other inflammatory diseases. Their therapeutic effects are considered to be mediated by four different mechanisms of action: the classical genomic mechanism of action caused by the cytosolic glucocorticoid receptor (cGCR); secondary non-genomic effects which are also ini...
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Glucocorticoids are the most effective therapy for the treatment of many chronic infl ammatory diseases such as asthma and infl ammatory bowel disease (Ito et al., 2006a). In contrast to the situation in asthma, chronic obstructive pulmonary disease (COPD), a common and debilitating chronic infl ammatory disease of the lung, is glucocorticoid insensitive (Barnes, 2000a, b; Culpitt et al., 2003)...
متن کاملMolecular mechanisms of glucocorticoid receptor signaling.
This review highlights the most recent findings on the molecular mechanisms of the glucocorticoid receptor (GR). Most effects of glucocorticoids are mediated by the intracellular GR which is present in almost every tissue and controls transcriptional activation via direct and indirect mechanisms. Nevertheless the glu-cocorticoid responses are tissue -and gene- specific. GR associates selectivel...
متن کاملMechanisms of glucocorticoid receptor action in noninflammatory and inflammatory cells.
Glucocorticoids exert profound and diverse physiological effects on a wide range of cell types. Produced and released from the adrenal cortex in response to stress, levels of glucocorticoids are under the control of the hypothalamic–pituitary–adrenal axis. Glucocorticoids participate in numerous physiological processes such as glucose homeostasis; protein, lipid, and carbohydrate metabolism; de...
متن کامل[Molecular mechanism of glucocorticoid action].
Glucocorticoids act on target cells via two isoforms of intracellular glucocorticoid receptors (GRs) called GRα (hormone-binding form) and GRβ which does not bind any glucocorticoids. A cycle of Hsp90 chaperone and co-chaperones maintains the functional status of GRs and their recycling. The binding of a glucocorticoid hormone to GRα leads to its activation and translocation from the cytoplasm ...
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ژورنال
عنوان ژورنال: Molecular and Cellular Endocrinology
سال: 2007
ISSN: 0303-7207
DOI: 10.1016/j.mce.2007.05.019